Preclinical data

Selected composition :

  • Drug1 : Antagonist of 5HT2 and 5HT1C receptors used in the treatment of allergy
  • Drug2 : Antagonist of alpha1-adrenergic receptors used in the treatment of arterial high blood pressure

Addiction to alcohol :

Effects of the combination on the alcohol intake and on preference to alcohol.

KT-110_activity
The preference to alcohol (vs. water) is studied on five groups of animals treated according to the legend

Drug1 + Drug2 in combination (KT-110 of Kinnov Therapeutics) reduces preference to alcohol and induces a strong alcohol aversion.

Addiction to nicotine :

Effects of KT-110 on behavioral sensitization to nicotine.

Locomotor Activity induced by Nicotine in mice
  • Nicotine induces an hyperactivity that becomes more marked after the 2nd and 3rd injections (Behavioral Sensitization).
  • KT-110 antagonizes behavioral sensitization induced by nicotine